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Inhibition of phenylalanine and tyrosine synthesis on Streptococcus faecalis and Lactobacillus arabinosus by alpha-keto acids



Inhibition of phenylalanine and tyrosine synthesis on Streptococcus faecalis and Lactobacillus arabinosus by alpha-keto acids



Arch. Biochem. Biophys, 61: 128-136



The growth responses of Streptococcus faecalis and Lactobacillus arabinus in media deficient in tyrosine or phenylalanine were studied when pyridoxamine and amino and alpha -keto acids were added. In the absence of tyrosine or phenylalanine, pyridoxamine was a powerful growth stimulant. In the absence of tyrosine, p-hydroxyphenylpyruvic acid stimulated, and phenylpyruvic acid inhibited, growth even with added pyridoxamine. In the absence of phenylalanine the roles of p-hydroxyphenylpyruvic acid and phenylpyruvic acid were reversed. The results are discussed with reference to the importance of pyridoxamine in transamination reactions with alpha -keto acids.

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Accession: 014082896

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PMID: 13292947


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