+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibition of some metalloprotein enzymes by 3-amino-1,2,4,-triazole

Inhibition of some metalloprotein enzymes by 3-amino-1,2,4,-triazole

Biochimica et Biophysica Acta 41: 485-491

Glucose oxidase is not inhibited by 3-amino-l,2,4-triazole(ATA). Tyrosinase and fatty acid peroxidase are inhibited by both ATA and imidazole. Lactoperoxidase is inhibited by ATA while horseradish peroxidase and the peroxidase found in seedlings are not inhibited. The inhibition of lactoperoxidase by ATA is easily reversed by dialysis against dilute saline. Increase in H2O2 does not overcome this inhibition. The relationship between ATA concentration and guaiacol (the reducing agent used in the peroxidase assay) concentration suggests non-competitive inhibition. The possible physiological significance of these findings is discussed.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 014082926

Download citation: RISBibTeXText

PMID: 13808268

DOI: 10.1016/0006-3002(60)90046-9

Related references

The crystal structures of three 3-methyl-1H-1,2,4-triazole-5-thio-nes, including a second polymorph of 4-[(E)-(5-bromo-2-hy-droxy-benzyl-idene)amino]-3-methyl-1H-1,2,4-triazole-5(4H)-thione and a redetermination of 4-amino-3-methyl-1H-1,2,4-triazole-5(4H)-thione. Acta Crystallographica. Section E Crystallographic Communications 71(Pt 9): 1003-1009, 2015

Late season foliage applications of amino triazole and amino triazole-benzoic combinations on Black Locust. Proc. 14th Ntheast. Weed Control Conf, 383, 1960

Effects of 3-amino-5-p-toluidino-1,2,4-triazole and 3-amino-l,2,4-triazole on tropic responses of lettuce and wheat seedlings. Weed Res 8(2): 151-152, 1968

Effect of 3-amino-5-H-toluidino-1,2,4-triazole and 3-amino-1,2,4-triazole on tropic responses of lettuce and wheat seedlings. Weed Res, 8: 2, 151-2. Bibl. 3, 1968

The influence of 3-amino-1,2,4-triazole upon the activities of certain enzymes from Cyperus rotundus L. Proc. 12th Sth. Weed Conf, 174, 1959

Prevention of halothane induced changes in rat liver enzymes by 3-amino-1,2,4-triazole. Biochemical Pharmacology 23(2): 403-409, 1974

Amino triazole salts and amino triazole-5-C14 studies on pigment production in cotton. Weeds, 5: 4, 304-315. bibl.11, 1957

The action of 3-amino-1,2,4-triazole on the activity of some enzymes of Sinapis alba seedlings. Meded. Rijksfac. LandbWet. Gent, 32: 3/4, 1036-9. Bibl. 7, 1967

The effect of 3-amino-1,2,4-triazole on respiration and oxidative enzymes of corn leaves. Abstr. Weed Soc. Amer, 40, 1958

Effect of 3 amino 1 2 4 triazole on the activity of some enzymes of seedlings of sinapis alba d. Mededelingen van de Rijksfaculteit Landbouwwetenschappen te Gent 32(3-4): 1036-1039, 1967

Mechanism of inhibition of catalase by 3-amino-l,2,4-triazole. Arch Biochem And Biophys 76(1): 32-44, 1958

A study of the inhibition of catalase by 3-amino-l24-triazole. Biochem Jour: 468-475, 1958