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Natural history of degenerative joint disease in small laboratory animals. I. Pathologic anatomy of degenerative joint disease in mice



Natural history of degenerative joint disease in small laboratory animals. I. Pathologic anatomy of degenerative joint disease in mice



Arch Pathol 62(2): 118-128



A detailed account of the pathological anatomy of spontaneous degenerative joint disease in 670 laboratory mice, 12-22 months old, is presented. Murine osteoarthritis closely simulates its human counterpart in anatomical features, localized distribution according to postural characteristics and its occurrence in older age groups. These considerations, the omnivorous dietary habits, short life span and the availability of highly inbred strains make the mouse a suitable experimental animal for the study of degenerative joint disease.

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Accession: 014113953

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PMID: 13354099


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