The coagulation defect in Rift Valley fever and yellow fever virus infections

Mims, C.A.

Annals of Tropical Medicine and Parasitology 50(2): 147-149


ISSN/ISBN: 0003-4983
PMID: 13340674
DOI: 10.1080/00034983.1956.11685752
Accession: 014230233

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Hemorrhagic phenomena are common in mice infected with pantropic strains of Rift Valley fever virus. Deter-minations of the quick one-stage prothrombin time were made on heart blood of such mice. Early in the disease prothrombin percentages were markedly depressed while the clotting time (capillary tube method) was normal. Later in the disease prothrombin levels were less than 5% of normal and the clotting time was prolonged. In 2 monkeys infected with yellow fever virus a fall in prothrombin content and prolongation of the clotting time were observed; the degree of these changes cor-responded to the degree of liver damage found post mortem in the 2 monkeys.