EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

The effects of actithiazic acid on egg white-induced biotin deficiency and upon the microbial formation of biotin vitamers in the rat



The effects of actithiazic acid on egg white-induced biotin deficiency and upon the microbial formation of biotin vitamers in the rat



Archives of Biochemistry and Biophysics 74(1): 7-16



Two biotin-like substances, "avidin uncombinable biotin" (AUB) and SC factor (avidin combinable but not "true" biotin), have been found in the supernatants of Escherichia coll cultures as well as in the urine and stool of the rat. The AUB and SC factors are normally produced in small quantities by E. coli, but under the influence of actithiazic acid (0.01 mg/ 8 ml culture) this production is increased 5 to tenfold. This increase of biotin vitamins was found in supernatants of cultures of crude rat stool flora, and in pure cultures of a coliform organism (isolated from this rat stool), as well as in similar cultures of a pure strain of E. coli K-12. These findings suggest an entire origin of the increased AUB and SC found in the urine of actithiazic acid treated rats. However, actithiazic acid (50 mg/rat/day subcutaneously) did not significantly increase or decrease the degree of biotin deficiency induced in the rat by administration of raw egg white.

(PDF emailed within 0-6 h: $19.90)

Accession: 014244614

Download citation: RISBibTeXText

PMID: 13522218

DOI: 10.1016/0003-9861(58)90194-2



Related references

Control action of actithiazic acid on the biosynthesis of biotin-vitamers by microorganisms. 1970

Studies on the metabolism of biotin vitamers by microorganisms part 2 conversion of 7 8 di amino pelargonic acid into dethio biotin and bis nordethio biotin by pseudomonas graveolens. Agricultural & Biological Chemistry 35(6): 877-884, 1971

Studies on the metabolism of biotin vitamers by microorganisms part 1 conversion of biotin di amino carboxylic acid into biotin and bis norbiotin by resting cell system. Agricultural & Biological Chemistry 35(6): 870-876, 1971

Metabolism of biotin and analogues of biotin by microorganisms. II. Further studies on the conversion of D-biotin to biotin vitamers by Lactobacillus plantarum. Journal of Bacteriology 92(4): 913-919, 1966

Studies on the metabolism of biotin vitamers by microorganisms part 3 purification and characterization of an enzyme synthesizing the ureido ring of biotin vitamers. Agricultural & Biological Chemistry 35(9): 1346-1352, 1971

Studies on degradation of d-biotin by microorganisms. II. THE isolation and characterization of unknown biotin vitamers produced from d-biotin by Endomycopsis sp. 1970

Metabolism of biotin and analogues of biotin by microorganisms II Further studies on the conversion of D-biotin vitamers by Lactobacillus plantarum. 1966

Studies on degradation of d biotin by microorganisms part 2 the isolation and characterization of unknown biotin vitamers produced from d biotin by endomycopsis sp. Agricultural & Biological Chemistry: 370-374, 1970

Studies on the bacterial production of biotin vitamers part 2 some properties of the unknown biotin vitamers. Nippon Nogeikagaku Kaishi 46(10): 517-523, 1972

Biotin Biosynthesis. I. Biotin Yields And Biotin Vitamers In Cultures Of Phycomyces Blakesleeanus. Journal of Bacteriology 86: 673-680, 1963

Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of biotin deficiency on gene expression and enzyme activities in mouse dam and fetus. Journal of Nutritional Biochemistry 16(7): 435-437, 2005

Characteristics of biotin vitamers produced from pimelic acid by a biotin producing bacterium. Agricultural and Biological Chemistry 41(7): 1153-1160, 1977