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Absorption of polyglutamic folate: participation of deconjugating enzymes of the intestinal mucosa



Absorption of polyglutamic folate: participation of deconjugating enzymes of the intestinal mucosa



New England Journal of Medicine 280(18): 985-988



Solutions containing 0.5 micro moles of conjugated folacin, calculated as the total activity for Lactobacillus casei after deconjugation minus that before it, were given by mouth to fasting adults. Serum samples were subsequently obtained for assay with L. casei. Free folate in serum rose to a peak 2 to 4 h after the test dose, and no conjugated activity could be detected. Everted sacs of rat jejunum were incubated with the conjugated folacin and were shown to release free folic acid.

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Accession: 014328790

Download citation: RISBibTeXText

PMID: 5777925

DOI: 10.1056/nejm196905012801804


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