Comparative antimony disposition following administration of tartar emetic and sodium antimony dimercaptosuccinate (Astiban) to hamsters infected with Schistosoma mansoni
Schulert, A.R.; Girgis, N.I.; Girgis, G.R.; Farid, Z.; McConnell, E.
East African Medical Journal 44(1): 1-8
ISSN/ISBN: 0012-835X PMID: 6038793 Accession: 014388058
Six weeks after hamsters were infected with Schistosoma mansoni cercariae, Sb124labelled drugs were given-tartar emetic at dosages ranging from 0.4 to 10 mg. per kg. body-weight, and Astiban from 25 to 150 mg. per kg. Reduction of the dose of tartar emetic produced an increase in the relative uptake of the drug by both host tissues and the worms. Reduction of the dose of Astiban resulted in an increase in relative uptake only by the worms. The results suggest that although tartar emetic is more favourable for elimination of female worms, Astiban would be more efficacious with divided lower doses.