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Effect Of Prenatal Diet On Serum Cholesteryl Ester Fatty Acids In Newborn And Adult Rats



Effect Of Prenatal Diet On Serum Cholesteryl Ester Fatty Acids In Newborn And Adult Rats



Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 118: 829-834



Pregnant rats were fed synthetic diets which differed in both quantity and fatty acid composition of fat, as well as in quantity and quality of protein. Serum cholesteryl ester fatty acids (CEFA), palmitate, oleate, linoleate and arachidonate, were determined on mother rats and neonates by quantitative glass paper chromatography. Lowered CEFA were observed in the low-protein dietary groups, in which "uterine inertia", small litters and sick or stillborn pups were common. Evidence was obtained confirming the existence of a typical "fetal" CEFA pattern in the neonates characterized by a high oleate: linoleate (O/L) ratio (1.5 to 5.0), and of a typical "adult" CEFA pattern in the mother rat characterized by an O/L ratio of less than unity (0.2 to 0.6). These characteristic "adult" and "fetal" CEFA patterns were found to be maintained in spite of moderate alterations in the fatty acid composition of the prenatal diets, but could not be maintained in the face of the exaggerated imbalance of diets supplying only single fatty acids. Based on the data obtained, it was postulated that homeostatic mechanisms exist which function so as to maintain the characteristic adult and fetal CEFA patterns in the face of stresses consisting of variations in the dietary fatty acid composition.

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Accession: 014443156

Download citation: RISBibTeXText

PMID: 14264572

DOI: 10.3181/00379727-118-29984


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