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Effects of accumulated tissue cholesterol on bile acid metabolism in hypophysectomized rats and hamsters



Effects of accumulated tissue cholesterol on bile acid metabolism in hypophysectomized rats and hamsters



Atherosclerosis. 12: 383-392



Female hamsters and rats and hypophysectomised female rats were given a basal diet for 1 month and cholesterol was estimated in blood and liver before and after a 3-week period with 1% cholesterol supplements. Cholic-24-14C or chenodeoxycholic acid was injected intraperitoneally. High concentrations of tissue cholesterol decreased bile acid half-lives in normal and hypophysectomised rats. In normal but not in hypophysectomised rats the cholic acid pool decreased and chenodeoxycholic acid pool increased but the total bile acid pool was constant. In hamsters, high tissue cholesterol levels caused a 3-fold increase in cholic acid pool and a 2.5-fold increase in cholic acid half-life but had little effect on chenodeoxycholic half-life or pool size.

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Accession: 014450714

Download citation: RISBibTeXText

PMID: 5497525

DOI: 10.1016/0021-9150(70)90042-0



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