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Human secretory immunoglobulins. IV. Quantitation of free secretory piece



Human secretory immunoglobulins. IV. Quantitation of free secretory piece



Acta path. microbiol. scand., B 79(2): 189-203



The immunoassay of the free secretory piece (SP) has been hampered previously because the conventional antisera did not distinguish between 'free' and 'bound' SP. The specific I determinant of free SP (see preceding abstr.) made it now possible to obtain antisera monospecific for it. Thus, free SP could be assayed by radial immunodiffusion in various human external secretions. There was a trend for the secretions with the highest concn. of SIgA to exhibit low ratios of free SP to SIgA. This may reflect a relatively increased consumption of SP through conjugation with IgA. Values for free SP are given for samples of colostrum (0.209 mu g/100 ml, with 1.318 g IgA), nasal secretion, sweat, and salivary secretions. The independent synthesis of IgA and SP appears to be certain as SP synthesis occurs also in secretions of hypo-immunoglobulin and IgA deficient patients, and because of its presence in infants before detectable production of IgA occurs. The function of SP, to stabilize the quaternary structure of locally produced IgA dimers, is discussed.

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Accession: 014509414

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PMID: 4996630


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