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Increased incidence of spontaneous mammary tumours in female rats with induced hypo-thalamic lesions



Increased incidence of spontaneous mammary tumours in female rats with induced hypo-thalamic lesions



Cancer Res, 30: 9, 2310-13



Bilateral lesions of the median eminence of Sprague-Dawley rats significantly increased (P <0.001) the number of mammary tumours developed when compared with non-operated controls (12 of 23 vs. 4 of 21) and significantly increased (P < 0.001) blood prolactin levels from 50.9 +or- 9.6 to 179.8 +or- 23.9 ng/ml. It is concluded that disruption of the final common pathway from the hypothalamus to the anterior pituitary can increase the incidence of mammary tumour development, possibly due to the increase in blood prolactin concn.

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Accession: 014517748

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PMID: 5529115


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