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Search for a specific therapy of trichinelliasis. Communication VII. The effect of acylation on the activity of drugs from the benzimidazole series in experimental trichinelliasis of white mice



Search for a specific therapy of trichinelliasis. Communication VII. The effect of acylation on the activity of drugs from the benzimidazole series in experimental trichinelliasis of white mice



Medskaya Parazit, E. I. Martsinovsky Inst. of Medical Parasitology and Tropical Medicine, Moscow, USSR. 40(5): 540-542



Nine thiabendazole derivatives (Preparations G-491, 572, 581, 669, 673, 719, 725, 726, 728) were tested against trichinelliasis in the mouse in the hope of revealing a more active chemical structure than thiabendazole. A comparison of the structure-activity relationships indicated that compounds substituted with CH3CO- or CH3COO- groups at the Nl terminal of the benzimidazole ring were of a similar activity to thiabendazole or less active.

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