Some factors controlling the incidence of scrapie in Cheviot sheep injected with a Cheviot-passaged scrapie agent

Dickinson, A.G.; Stamp, J.T.; Renwick, C.C.; Rennie, J.C.

Journal of Comparative Pathology 78(3): 313-321


ISSN/ISBN: 0021-9975
PMID: 4970193
DOI: 10.1016/0021-9975(68)90007-8
Accession: 014673408

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A gene ("sinc") in mice which controls the incubation period of the ME7 scrapie agent was identified. An aliele designated s7 shortens the incubation period and another (p7) prolongs it. The distribution and intensity of brain lesions were very similar in the two homozygotes, as represented by two mouse strains, and the heterozygote, as represented by the F1 cross. The possible modes of action of the two alieles of this gene are discussed.