Studies on the Metabolism of Alpha-Lipoic Acid in Childhood. Ii. Urinary Excretion of Alpha-Lipoic Acid in Children

Nakamura, T.; Kusunoki, T.; Konishi, S.; Kato, H.; Mibu, A.

Journal of Vitaminology 11: 54-59


ISSN/ISBN: 0022-5398
PMID: 14327736
Accession: 014695895

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For parts 1 and 3, on rats, see Abst. 527, Vol. 36. 2. The amount of lipoic acid excreted from 6 to 8 a.m. fasting by healthy children and children with kidney disorders was estimated with Streptococcus faecalis R; it increased with bodyweight, and the correlation was significant. In kidney disorders it was decreased, 15 mg per kg bodyweight on average, compared with 25 for normal children. When patients became thin through anorexia there was a large increase to over 50 mg per kg. After intravenous injection of 1 mg DL-lipoic acid per kg bodyweight values in blood and urine rose, but returned to normal after 6 h. Normal children excreted from 0.2 to 0.7% of the load, 90% of that within 2 h, those with kidney disorders very little, but they tended to excrete more as their condition improved.