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The Atherogenic Potential Of Dietary Derived Cholesterol

British Journal of Experimental Pathology 46: 1-5

The Atherogenic Potential Of Dietary Derived Cholesterol

Six groups of 5-10 male albino rabbits, 3 months of age, were fed cholesterol-free stock diet supplemented with 0.5% cottonseed oil; to each 100 g of diet consumed by the respective groups cholesterol was added in the following amounts: 5 mg, 50 mg, 100 mg, 250 mg, 500 mg and 1000 mg. A seventh group consumed unsupplemented stock diet. Each animal bore a developing thrombosclerotic plaque induced by insertion of a Zn coated Mg-Al alloy wire into the abdominal aorta. Quantities of fed cholesterol-50, 100, and 250 mg/100 g diet-insufficient to alter serum cholesterol concentration or to promote deposition of excess lipid and cholesterol in the intact aorta were observed to promote such accumulation in the induced plaque. The results suggest dietary derived cholesterol provides an increased atherogenic potential to any arterial area in which hyperplasia is in process.

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Accession: 014718143

PMID: 14295556

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