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The effect of 28-day pesticide feeding on serum and tissue enzyme activities of rats fed diets of varying casein content

Casterline, J.L.; Williams, C.H.

Toxicology and Applied Pharmacology 18(3): 607-618

1971


ISSN/ISBN: 0041-008X
PMID: 5569834
DOI: 10.1016/s0041-008x(71)80015-7
Accession: 014728865

Female and male rats were given diets containing 19, 8 or 3% casein with no pesticide or with pesticides at different concentrations for 28 days. In rats of both sexes given diets with no pesticide, the liver triacetinesterase (AliE) activity was related to the amount of casein eaten. The serum cholinesterase (ChE) activity of females also decreased with decreasing casein but in males was reduced only in those given 8% casein. Serum AliE activity was most with 8 and 3% casein. ChE activity in brain, beta -glucuronidase ( beta Glu) activity in serum and aniline hydroxylase activity in liver were the same at all casein levels. The activity of p-nitroreductase was reduced with low casein. In those given pesticide, chlordane-induced increases in liver AliE, aniline hydroxylase and pnitroreductase activities were dependent on pesticide dose. Increases in serum AliE activity were dependent on both pesticide dose and casein intake. Chlordane reduced serum beta -Glu more at 8 than at the 19% casein. Parathion-induced inhibition of serum ChE, serum and liver AliE and brain ChE increased with increasing dose and with decreasing casein. Parathion increased serum beta -Glu activity to the same degree at all casein levels. Banol-induced inhibition of ChE in the serum was pronounced with low casein. The increase in serum AliE by Banol followed the decrease in casein, inhibition of liver AliE was independent of casein intake and was dose-dependent. Banol did not affect beta -Glu.

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