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The Jejunal Mucosa in Patients with Nutritional Folate Deficiency and Megaloblastic Anemia



The Jejunal Mucosa in Patients with Nutritional Folate Deficiency and Megaloblastic Anemia



New England Journal of Medicine 272: 892-895



Sixteen peroral jejunal biopsies were performed in 6 patients with nutritional folate deficiency. All patients had mild to severe megaloblastic changes at the time of biopsy, hematocrits varying from a borderline value of 41.9% to a low value of 13.5%. Jejunal morphologic changes were minor and consisted of minimal mononuclear-cell infiltration in the lamina propria in 3 patients and questionable shortening of the villi in 1. The disparity between the prominent hematologic and the minimal jejunal morphologic changes suggests that abnormalities in the jejunal mucosa may occur only as a late event in severe nutritional folate deficiency when uncomplicated by some other process such as tropical sprue.

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Accession: 014753401

Download citation: RISBibTeXText

PMID: 14274441

DOI: 10.1056/nejm196504292721705


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