The nature of localized chromosome breakage induced by ethyl methanesulfonate in Vicia faba

Ward, O.G., J.

Dissertation Abstracts International. B. The Sciences and Engineering 27: 3791-3792


ISSN/ISBN: 0419-4217
Accession: 014757330

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It was thought that actinomycin D would reduce the breakage effects of ethyl methane-sulphonate (EMS) by complexing with DNA guanine, but it did not prevent guanine alkylation and depurination in vitro by EMS. Breaks and achromatic gaps occurred in the S and M chromo-somes with EMS, and actinomycin interfered with chromosome condensation and induced localized breaks also.