The probability of fixation of a mutant: the two-locus case
Evolution. Lawrence, Kans., 21: 532-540
If the genes at 2 loci act independently, the probability of survival is independent of the degree of linkage between the loci. If there is interaction between the gene effects, then contrary to the behaviour to be expected from a deterministic treatment, there exist many situations where decreased linkage between the loci increases the probability of survival of the mutant. In many cases there appears to be an optimum intermediate value for the degree of linkage.