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Toxicity of Berenil in the dog

Toxicity of Berenil in the dog

Veterinary Record 85(7): 196

ISSN/ISBN: 0042-4900

Four pairs of healthy dogs were injected i/m into the thigh with Berenil (diminazene) at 10, 15, 20 or 60 mg/kg. One dog given 15 mg/kg and all four given the higher doses began to show nervous symp toms, including spastic paralysis, opisthotonus and nystagmus, and died 36-54 hours after the inoculation. Localized intramuscular haemorrhage, diffuse inter-muscular oedema around the inoculation site and extensive malacia in the mesencephalon and dien-cephalon were observed at P.M. examination.

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Accession: 014784498

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