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Tryptophan utilization in a threonine-induced amino acid imbalance in weanling rats: plasma amino acid and liver pyridine nucleotide concentrations



Tryptophan utilization in a threonine-induced amino acid imbalance in weanling rats: plasma amino acid and liver pyridine nucleotide concentrations



J. Nutrition. 91: 429-440



Weanling male rats were given diets containing 8% casein supplemented with methionine (control) or further supplemented with threonine, lysine, phenylalanine and histidine to give a threonine imbalance. Both diets were given either freely or the protein portions were given twice a day with the protein-free portion freely. All experiments lasted for 2 weeks. Growth was similar in the group given the control diet freely and when the protein portion of the control and imbalanced diets were given separately, but was slower when the imbalanced diet was given freely and was associated with a reduced food intake. In a second experiment rats were fed as in the first experiment for 1 week, then during the second week they were divided into 3 sub-groups, one continued on the initial diet, the others given the control or imbalanced diets but the method of feeding changed, i.e. free feeding was followed by "separate" feeding and vice versa. Growth was invariably retarded when the imbalanced diet was given freely. In a final experiment rats were killed 4 or 24 h after their final protein meal. Blood was analysed for amino acids and liver for pyridine nucleotides. Plasma threonine was elevated, even after 24 h, in rats given the imbalanced diet, but the effect was less with free than with separate feeding. There was no appreciable change in concentrations of other amino acids. There was no significant difference in concentrations of liver pyridine nucleotides attributable to protein source or to method of feeding. Concentrations were higher in animals killed 24 h after feeding than in those killed after 4 h.

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Accession: 014790442

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PMID: 6039021


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