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Advances in the research on bacterial multi-drug resistance efflux pump inhibitors



Advances in the research on bacterial multi-drug resistance efflux pump inhibitors



Zhongguo Kangshengsu Zazhi 32(4): 211-216,244



Bacterial resistance to antibiotics, especially the multi-drug resistance (MDR) has become a serious problem of healthcare. The existence of various kinds of efflux pumps is one of the important mechanisms of bacterial resistance. It is exigent to discover the efflux pump inhibitors which could be used in clinic. So far, various kinds of efflux pump inhibitors have been discovered. Their mechanisms of action are (1) interfering the assembling of efflux pumps, (2) blocking the energy supply of efflux pumps, (3) hindering the transit of substrates through the efflux tunnel and (4) unknown mechanism. According to the mechanisms of action, the characters of bacterial multi-drug resistance efflux pump inhibitors discovered by far were summarized in this review.

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Accession: 014962181

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