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Alteration of lung lipids in ozone exposed rats

Alteration of lung lipids in ozone exposed rats

Biochemical and Biophysical Research Communications 68(4): 1256-1262

ISSN/ISBN: 0006-291X

PMID: 1267778

DOI: 10.1016/0006-291x(76)90332-6

Exposure of adult male rats to 1.1 ± 0.3 ppm of ozone gave a 10-fold elevation of arachidonic acid in the lipid of the endobronchial washings. Arachidonate and linoleate increased in the cholesteryl esters from 6.5% to 55.5% and 4.7% to 20.4%, respectively. Similar changes also occurred in the composition of phosphatidyl choline. Serum lecithin:cholesterol acyl transferase (LCAT) activity was increased by exposure to ozone and returned to normal levels upon reexposure to an atmosphere of uncontaminated air. The results suggest that the lipid enzyme systems are strongly influenced by ozone exposure.

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Accession: 014998082

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