EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder



Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder



Genes, Brain, and Behavior 6(5): 444-452



The glutamatergic signaling pathway represents an ideal candidate susceptibility system for attention-deficit/ hyperactivity disorder (ADHD). Disruption of specific N-methyl-D- aspartate-type glutamate receptor subunit genes (GRIN1, 2A-D) in mice leads to significant alterations in cognitive and/or locomotor behavior including impairments in latent learning, spatial memory tasks and hyperactivity. Here, we tested for association of GRIN2B variants with ADHD, by genotyping nine single nucleotide polymorphisms (SNPs) in 205 nuclear families identified through probands with ADHD. Transmission of alleles from heterozygous parents to affected offspring was examined using the transmission/disequilibrium test. Quantitative trait analyses for the ADHD symptom dimensions [inattentive (IA) and hyperactive/impulsive (HI)] and cognitive measures of verbal working memory and verbal short-term memory were performed using the FBAT program. Three SNPs showed significantly biased transmission (P < 0.05), with the strongest evidence of association found for rs2284411 (chi(2) = 7.903, 1 degree of freedom, P = 0.005). Quantitative trait analyses showed associations of these markers with both the IA and the HI symptom dimensions of ADHD but not with the cognitive measures of verbal short-term memory or verbal working memory. Our data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait.

(PDF same-day service: $19.90)

Accession: 015093175

Download citation: RISBibTeXText

PMID: 17010153

DOI: 10.1111/j.1601-183X.2006.00273.x



Related references

Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Genes, Brain, and Behavior 7(1): 53-60, 2007

Association study of the nicotinic acetylcholine receptor alpha 4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Genes Brain and Behavior 7(1): 53-60, 2008

Association of the GRIN2B rs2284411 polymorphism with methylphenidate response in attention-deficit/hyperactivity disorder. Journal of Psychopharmacology: -, 2016

Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology 174(4): 530-538, 2004

Nicotinic acetylcholine receptor 7 subunit gene and attention deficit hyperactivity disorder. American Journal of Medical Genetics 96(4): 490, August 7, 2000

Nicotinic acetylcholine receptor alpha4 subunit gene polymorphism and attention deficit hyperactivity disorder. Psychiatric Genetics 11(1): 37-40, 2001

Association analysis of dopamine D4 receptor gene polymorphism and attention deficit hyperactivity disorder with/without disruptive behavior disorder. Beijing Da Xue Xue Bao. Yi Xue Ban 39(3): 233-236, 2007

Further evidence for the association between attention deficit/hyperactivity disorder and the serotonin receptor 1B gene. Journal of Neural Transmission 116(12): 1675-1680, 2010

Cardiovascular considerations of attention deficit hyperactivity disorder medications: a report of the European Network on Hyperactivity Disorders work group, European Attention Deficit Hyperactivity Disorder Guidelines Group on attention deficit hyperactivity disorder drug safety meeting. Cardiology in the Young 22(1): 63-70, 2012

Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 165b(4): 373-380, 2015

Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder. Annals of Human Genetics 71(Pt 5): 648-659, 2007

Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry 31(7): 1444-1448, 2007

Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 147(3): 316-319, 2007

Glutamate receptor, ionotropic, N-methyl d-aspartate 2A gene as a positional candidate for Attention-Deficit/Hyperactivity Disorder in the 16p13 region. American Journal of Medical Genetics 122B(1): 79, September 15, 2003

Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit/hyperactivity disorder. Neuropsychobiology 50(3): 231-234, 2004