Biosynthesis of melanotropins and endorphins by the lead-haematoxylin positive cells in pars intermedia of the cichlid teleost Sarotherodon mossambicus

Eys, G.-Van; Lowik, C.; Cruijsen, P.; Bonga, S.

Comparative biochemistry and physiology B Comparative biochemistry 7(1): 135-142


DOI: 10.1016/0305-0491(84)90235-9
Accession: 015157439

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1.1. Biosynthesis in the lead-haematoxylin positive pars intermedia cells of Sarotherodon mossambicus was analysed by SDS and acid-urea electrophoresis and high pressure liquid chromatography.2.2. Pulse and pulse-chase experiments revealed that a non-glycosylated 30K-precursor was processed into a number of smaller products.3.3. Melanotropic and endorphin-like peptides appeared to be the final products of this precursor-product processing.4.4. Our results indicate that the biosynthetic pathways in the lead-haematoxylin positive cells in the teleost pars intermedia are similar to those described for pars intermedia cells in other vertebrate groups.