+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Characterizing anterior cingulate activation in chronic schizophrenia: a group and single-subject fMRI study



Characterizing anterior cingulate activation in chronic schizophrenia: a group and single-subject fMRI study



Acta Psychiatrica Scandinavica 116(4): 271-279



Functional abnormalities of the dorsal anterior cingulate (dAC) region have been emphasized in schizophrenia, particularly in relation to cognitive deficits. In this study, we sought to further evaluate the notion of dAC hypofunction in chronic schizophrenia patients using a cognitive task specifically designed to activate this region, enabling both group and single-subject level analyses. Twelve male schizophrenia patients and 14 male healthy subjects were studied with functional magnetic resonance imaging (fMRI) and the multi-source interference task (MSIT). Patients and healthy subjects were matched for age, gender, education, task performance and gross surface morphology of the AC region. fMRI analyses were conducted at the group and single-subject levels using stringent whole-brain activation thresholds. Multi-source interference task performance was associated with large and significant activation of the dAC and supplementary motor area (SMA) in patients and healthy subjects. Standard comparison of the two groups indicated that the patients were comparable with healthy subjects in their dAC activation, but had a small cluster of greater SMA activation, while single-subject analyses identified minimal differences in the magnitude or spatial dispersion of dAC activation between the groups. These findings challenge existing notions of impaired dAC activation in chronic schizophrenia and suggest that the functional pathophysiology of this medial-wall region should be considered beyond straightforward models of hypoactivation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 015253769

Download citation: RISBibTeXText

PMID: 17803757

DOI: 10.1111/j.1600-0447.2007.01002.x


Related references

Schizophrenia symptom and functional correlates of anterior cingulate cortex activation to emotion stimuli: An fMRI investigation. Psychiatry Research 234(3): 285-291, 2016

FMRI study of prefrontal and anterior cingulate cortex during response competition in schizophrenia. Society for Neuroscience Abstracts 27(1): 307, 2001

Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. Journal of Affective Disorders 82(2): 191-201, 2004

Single-trial coupling of EEG and fMRI reveals the involvement of early anterior cingulate cortex activation in effortful decision making. Neuroimage 42(1): 158-168, 2008

Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: an event-related fMRI study. American Journal of Psychiatry 158(9): 1423-1428, 2001

No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No-go task: an fMRI study. Bipolar Disorders 11(3): 270-279, 2009

Is dorsal anterior cingulate cortex activation in response to social exclusion due to expectancy violation? An fMRI study. Frontiers in Evolutionary Neuroscience 4: 11, 2012

Sadness enhances the experience of pain via neural activation in the anterior cingulate cortex and amygdala: an fMRI study. Neuroimage 50(3): 1194-1201, 2010

Analysis of activation in anterior cingulate cortex during cognitive process of selection following somatosensory stimuli: fMRI study with elaborate task paradigms. Magnetic Resonance Imaging 18(4): 397-404, 2000

Abnormal anterior cingulate activation during cognitive inhibition in schizophrenia An evoked functional MRI study. Society for Neuroscience Abstracts 24(1-2): 1176, 1998

Variability in functional neuroanatomy in schizophrenia Group vs single-subject PET activation data. Society for Neuroscience Abstracts 24(1-2): 1238, 1998

Anterior cingulate activation during Stroop task performance: a PET to MRI coregistration study of individual patients with schizophrenia. American Journal of Psychiatry 159(2): 251-254, 2002

Nicotine effects on anterior cingulate cortex in schizophrenia and healthy smokers as revealed by EEG-informed fMRI. Psychiatry Research 204(2-3): 168-177, 2013

Cognitive and neural strategies during control of the anterior cingulate cortex by fMRI neurofeedback in patients with schizophrenia. Frontiers in Behavioral Neuroscience 9: 169, 2015

Increased activation of the supragenual anterior cingulate cortex during visual emotional processing in male subjects with high degrees of alexithymia: an event-related fMRI study. PsychoTherapy and Psychosomatics 79(6): 363-370, 2011