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Determination of the biological reactivity of ketoconazole in shampoo: draize eye test and cytotoxity test



Determination of the biological reactivity of ketoconazole in shampoo: draize eye test and cytotoxity test



Revista Brasileira de Ciencias Farmaceuticas 43(2): 301-307



Ketoconazole is an antifungal agent that can be incorporated into several formulations, such as shampoos and creams. The aim of this work was to assess the biological reactivity in vivo (Draize eye test) and in vitro (cytotoxity test) of ketoconazole in shampoo exposed to ultraviolet (UV) C (254 nm) radiation. Quantitative determination of ketoconazole was carried out using HPLC and microbiological assay. UV exposure decreased the antifungal activity of ketoconazole.

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Accession: 015475446

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