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Direct effects of diethylstilbestrol (DES) and estradiol on the rat given at low doses in the ration. practical consequences






Folia veterinaria latina: 5 (1) 27-44

Direct effects of diethylstilbestrol (DES) and estradiol on the rat given at low doses in the ration. practical consequences



Accession: 015516380



Related references

Valette J.P., 1975: Direct effects on the rat of di ethyl stilbestrol and estradiol given at low doses in the ration practical consequences. Folia Veterinaria Latina: 27-44

Ferrando, R.; Valette, J.P., 1975: Direct effects on the rat of diethylstilboestrol (DES) and oestradiol given at low doses in the ration. Practical consequences. Studies in male and female rats on the direct effects of DES in the diet at 60 and 120 mu g/kg of food and oestradiol at 120 and 240 mu g/kg of food showed that DES impaired growth and reproductive capacity. Oestradiol did not have these effects....

Ferrando, R.; Valette, J.P., 1975: Direct effects on the rat of diethylstilboestrol (DES) and oestradiol given at low doses in the diet. Practical consequences. 23-day-old male and female Wistar rats were given 60 or 120 mu g DES, or 120 or 240 mu g oestradiol/kg food. The animals were weighed twice weekly for 3 mth and thereafter weekly. Oestradiol at either level had no significant effect on growth rate...

Vom Saal, F.S.; Timms, B.G.; Montano, M.M.; Palanza, P.; Thayer, K.A.; Nagel, S.C.; Dhar, M.D.; Ganjam, V.K.; Parmigiani, S.; Welshons, W.V., 1997: Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. On the basis of results of studies using high doses of estrogens, exposure to estrogen during fetal life is known to inhibit prostate development. However, it is recognized in endocrinology that low concentrations of a hormone can stimulate a tiss...

Alworth, L.C.; Howdeshell, K.L.; Ruhlen, R.L.; Day, J.K.; Lubahn, D.B.; Huang, T.H.M.; Besch-Williford, C.L.; vom Saal, F.S., 2002: Uterine responsiveness to estradiol and DNA methylation are altered by fetal exposure to diethylstilbestrol and methoxychlor in CD-1 mice: effects of low versus high doses. We examined the effects on female CD-1 mice of fetal exposure to low doses of the drug diethylstilbestrol (DES) (0.1 microg/kg/day) and the insecticide methoxychlor (MXC) (10 microg/kg/day) as well as 1000-fold higher doses: 100 microg/kg/day DES...

Alworth, L.C.; Howdeshell, K.L.; Ruhlen, R.L.; Day, J.K.; Lubahn, D.B.; Huang, T.H.M.; Besch Williford, C.L.; Vom Saal, F.S., 2002: Uterine responsiveness to estradiol and DNA methylation are altered by fetal exposure to diethylstilbestrol and methoxychlor in CD-1 mice: Effects of low versus high doses. We examined the effects on female CD-1 mice of fetal exposure to low doses of the drug diethylstilbestrol (DES) (0.1 microg/kg/day) and the insecticide methoxychlor (MXC) (10 microg/kg/day) as well as 1000-fold higher doses: 100 microg/kg/day DES...

Sower S.A.; Dickhoff W.W.; Flagg T.; Mighell J.; Mahnken C., 1985: Sex reversal in atlantic salmon problems with high doses of estradiol and diethylstilbestrol. Iwamoto, R N And S Sower (Ed ) Salmonid Reproduction: An International Symposium; Meeting, Bellevue, Wash , Usa, Oct 31-Nov 2, 1983 Vii+167p Washington Sea Grant Program: Seattle, Wash , Usa Illus Paper 40-41

Henry, E.C.; Miller, R.K.; Baggs, R.B., 1984: Direct fetal injections of diethylstilbestrol and 17 beta-estradiol: a method for investigating their teratogenicity. The synthetic estrogen, diethylstilbestrol (DES), causes urogenital malformations in humans, primates, and rodents. This study was designed to determine whether these effects of DES are related to its estrogenicity. Therefore, DES (0.1, 1, and 10...

Koong, L.Y.; Watson, C.S., 2014: Direct estradiol and diethylstilbestrol actions on early- versus late-stage prostate cancer cells. Diethylstilbestrol (DES) and other pharmaceutical estrogens have been used at ≥ µM concentrations to treat advanced prostate tumors, with successes primarily attributed to indirect hypothalamic-pituitary-testicular axis control mechanisms. Howe...

Simon, K.J.; Swenson, M.J.; Davison, F.C., 1963: Effects of diethylstilbestrol on blood cholesterol, hemogram, and testes of cockerels fed a ration low in zinc. From hatching 2 groups of 25 male chickens were fed on a diet based on maize and soya bean meal, with about 20 p.p.m. Zn. One group got 7.5 g stilboestrol per 100 lb diet. A syndrome resembling Zn deficiency developed in 38 % of the chickens not g...