EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Direct renal hemodynamic effects of clonidine


Archives Internationales de Pharmacodynamie et de Therapie 218(2): 202-211
Direct renal hemodynamic effects of clonidine
The renal hemodynamic and excretory effects of clonidine were tested in 2 groups of dogs. In one group, the drug was given directly into the renal artery at a rate of 1.2 mug/min and resulted in a significant decrease of the effective renal plasma flow (ERPF) in both kidneys, an increase in filtration fraction (F.F.), urine volume (U.V.), and free water clearance (CH2O) and had no effect upon the glomerular filtration rate (GFR), osmolar clearance (Cosm) and the excretion of sodium (UNa+V), chloride (UC1-V), potassium (UK+V), calcium (UCa++V) and phosphorous (UP04V). In the second group of animals it was given intravenously at a rate of 12.0 mug/min and resulted in a significant decrease of ERPF, UNa+V, UC1-V, and an increase in F.F., U.V. and CH2O and had no effect upon GFR, Cosm, UK+V, UCa++V and UPO4V. Systemically, it decreased heart rate (H.R.) and respiratory rate (R.R.) in both groups of animals; it increased blood pressure (BP) in Group I and had no effect on BP in Group II.


Accession: 015516906

PMID: 1212018



Related references

Hemodynamic and renal effects of high epidural clonidine doses in dogs. Revista Brasileira de Anestesiologia 55(3): 308-315, 2005

The direct renal hemodynamic effects of lovastatin. FASEB Journal 9(3): A301, 1995

Direct renal hemodynamic effects of two vasodilators: diazoxide and acetylcholine. Archives Internationales de Pharmacodynamie et de Therapie 217(1): 44-56, 1975

Lovastatin has direct renal hemodynamic effects in a rodent model. Journal Of Urology. 156(1): 249-252, 1996

Analgesic and hemodynamic effects of epidural clonidine, clonidine/morphine, and morphine after pancreatic surgery--a double-blind study. Anesthesia and Analgesia 80(5): 869-874, 1995

Direct renal hemodynamic effects of indomethacin furosemide and prostaglandin e 1 in anesthetized dogs. Federation Proceedings 39(3): ABSTRACT 3587, 1980

Direct renal hemodynamic effects of 2 vaso dilators diazoxide and acetyl choline. Archives Internationales de Pharmacodynamie et de Therapie 217(1): 44-56, 1975

Hemodynamic effects of moxonidine and clonidine. Journal of Molecular & Cellular Cardiology 22(SUPPL 3): S18, 1990

Hemodynamic and cardiac effects of clonidine. Journal of Cardiovascular Pharmacology 2 Suppl 1: S39-S46, 1980

Action of clonidine in the morphine withdrawal syndrome lack of effects of p amino clonidine and differential blockade of clonidine effects by yohimbine. Research Communications in Substances of Abuse 4(2): 97-114, 1983