Effects of 1,25- and 24,25-dihydroxyvitamin D3 on bone formation in the cichlid teleost Sarotherodon mossambicus

Wendelaar Bonga, S.E.; Lammers, P.I.; van der Meij, J.C.

Cell and Tissue Research 228(1): 117-126

1983


ISSN/ISBN: 0302-766X
PMID: 6600970
DOI: 10.1007/bf00206270
Accession: 015647567

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Abstract
1,25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 have antagonistic effects on the acellular bone of the tilapia Sarotherodon mossambicus. 1,25-Dihydroxyvitamin D3 inhibits the activity of the lining osteoblasts. Prolonged administration leads to demineralization of the bone matrix. Injection of 24,25-dihydroxyvitamin D3 induces structural signs of greatly enhanced appositional bone growth within three days. No effects were observed on the mineral content of pre-existing bone. Both 1,25- and 24,25-dihydroxyvitamin D3 may have distinct, but different physiological functions in fish.

Effects of 1,25- and 24,25-dihydroxyvitamin D3 on bone formation in the cichlid teleost Sarotherodon mossambicus