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Effects of prochloraz on drug metabolism in the Japanese quail, grey partridge, chicken, and pheasant



Effects of prochloraz on drug metabolism in the Japanese quail, grey partridge, chicken, and pheasant



Archives of Environmental Contamination and Toxicology 14(3): 299-306



Prochloraz (N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide) is a new agricultural fungicide. When administered in the diet, it induced hepatic and intestenal cytochrome P-450 levels and monooxygenase activities from Japanese quail (C. coturnix), gray partridge (P. perdix), chicken (G. gallus) and pheasant (P. colchicus). After administration of a single dose to quail, prochloraz acted biphasically, i.e., inhibited, then induced aniline hydroylase activity. In close relation with this biphasic pattern, pentobarbital sleeping time and toxicity of the insecticide parathion were modified. Admnistration of prochloraz at various dose levels in the diet of quail did not influence fecundity, fertility and development progeny.

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Accession: 015667845

Download citation: RISBibTeXText

PMID: 4004337

DOI: 10.1007/bf01055406


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