EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Fourth expansion and glucose perturbation of the Dictyostelium kinetic model


, : Fourth expansion and glucose perturbation of the Dictyostelium kinetic model. European Journal of Biochemistry 74(2): 217-225

The kinetic model of carbohydrate metabolism has been expanded to include: (a) the accumulation of alpha and beta-cellulose, insoluble cell-wall glycogen and mucopolysaccharide; (b) the role of RNA turnover as a source of carbon for end-product synthesis and as a buffer regulating the level of uridine nucleotides in this metabolic network; and (c) the role of purine-nucleoside phosphorylase, 5'-AMP nucleotidase, nucleosidediphosphate kinase and polynucleotide phosphorylase. One of many predictions based on this model is that cells differentiating in the presence of glucose will produce sorocarps with an abnormally high trehalose to cellulose ratio. External perturbation of either the model or of developing cells by glucose increases the levels of sorocarp trehalose and glycogen, 5-fold and 6-fold respectively. Evaluation of the experimental data and the simulation analyses have allowed several predictions to be made concerning the compartmentation of metabolites and the permeability of cells to glucose during differentiation.


Accession: 015885653

PMID: 558094

DOI: 10.1111/j.1432-1033.1977.tb11384.x

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Wright, B.E.; Tai, A.; Killick, K.A., 1977: 4th expansion and glucose perturbation of the dictyostelium discoideum kinetic model. The kinetic model of carbohydrate metabolism was expanded to include: the accumulation of .alpha. and .beta.-cellulose, insoluble cell-wall glycogen and mucopolysaccharide; the role of RNA turnover as a source of C for end-product synthesis and as...

Wright, B.E.; Gustafson, G.L., 1972: Expansion of the kinetic model of differentiation in Dictyostelium discoideum. Journal of Biological Chemistry 247(24): 7875-7884

Wright, B.; Simon, W.; Walsh, B.T., 1968: A kinetic model of metabolism essential to differentiation in dictyostelium discoideum enz udp glucose pyro phosphorylase. Proceedings of the National Academy of Sciences of the United States of America 60(2): 644-651

Perdew; Sahni; Harbola; Pathak, 1986: Fourth-order gradient expansion of the fermion kinetic energy: Extra terms for nonanalytic densities. Physical Review. B, Condensed Matter 34(2): 686-691

Kelleher, J.K.; Kelly, P.J.; Wright, B.E., 1978: A kinetic analysis of glucokinase and glucose-6-P phosphatase in Dictyostelium. Using a mathematical model of carbohydrate metabolism in Dictyostelium discoideum, the kinetic expressions describing the activities of glucokinase and glucose-6-P phosphatase have been analyzed. The constraints on the kinetic mechanisms and relat...

Perdew; Sahni; Harbola; Pathak, 1988: Erratum: Fourth-order gradient expansion of the fermion kinetic energy: Extra terms for nonanalytic densities. Physical Review. B, Condensed Matter 37(8): 4267-4267

Li, R-Dong.; Li, Y-Yuan.; Lu, L-Yi.; Ren, C.; Li, Y-Xue.; Liu, L., 2011: An improved kinetic model for the acetone-butanol-ethanol pathway of Clostridium acetobutylicum and model-based perturbation analysis. Comprehensive kinetic models of microbial metabolism can enhance the understanding of system dynamics and regulatory mechanisms, which is helpful in optimizing microbial production of industrial chemicals. Clostridium acetobutylicum produces solve...

Reimers, J.M.; Huang, Q.; Albe, K.R.; Wright, B.E., 1993: Purification and kinetic characterization of glucose-6-phosphate dehydrogenase from Dictyostelium discoideum. Glucose-6-phosphate dehydrogenase from Dictyostelium discoideum was purified 650-fold and kinetically characterized. The enzyme catalyzed the conversion of G6P + NADP to 6PG + NADPH stoichiometrically and irreversibly in vitro. The purified enzyme...

Mazenko, 2000: Perturbation expansion in phase-ordering kinetics. II. N-vector model. The perturbation theory expansion presented earlier to describe the phase-ordering kinetics in the case of a nonconserved scalar order parameter is generalized to the case of the n-vector model. At lowest order in this expansion, as in the scalar...

Kelleher, J.K.; Kelly, P.J.; Wright, B.E., 1978: A kinetic analysis of gluco kinase and glucose 6 phosphate phosphatase in dictyostelium discoideum. Using a mathematical model of carbohydrate metabolism in D. discoideum, the kinetic expressions describing the activities of glucokinase and glucose-6-P [phosphate] phosphatase were analyzed. The constraints on the kinetic mechanisms and relative...