Section 16
Chapter 15,983

Haematological abnormalities induced by feeding a common artificial sweetener, saccharin, in ICR Swiss mice

Prasad, O.; Rai, G.

Toxicology Letters 36(1): 81-88


ISSN/ISBN: 0378-4274
PMID: 3564072
DOI: 10.1016/0378-4274(87)90044-0
Accession: 015982239

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Haematological studies were carried out to investigate the possible deleterious effects of an extensively used artificial sweetener, saccharin, on albino mice, after feeding it for 1 year at the rate of 0.0 (control), 0.5, 1.0 and 1.5 g/kg body weight/day. Feeding of the chemical at 1.0 and 1.5 g/kg/day revealed a marked decrease in total erythrocyte count (TEC), haemoglobin content (Hb) and packed cell volume (PCV), suggesting the occurrence of anaemia. Differential leucocyte count (DLC) showed a marked increase in the number of polymorphonuclear neutrophils. Saccharin toxicity, in terms of induction of haematological abnormalities in albino mice, is discussed.

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