Haematological abnormalities induced by feeding a common artificial sweetener, saccharin, in ICR Swiss mice
Prasad, O.; Rai, G.
Toxicology Letters 36(1): 81-88
ISSN/ISBN: 0378-4274 PMID: 3564072 DOI: 10.1016/0378-4274(87)90044-0
Haematological studies were carried out to investigate the possible deleterious effects of an extensively used artificial sweetener, saccharin, on albino mice, after feeding it for 1 year at the rate of 0.0 (control), 0.5, 1.0 and 1.5 g/kg body weight/day. Feeding of the chemical at 1.0 and 1.5 g/kg/day revealed a marked decrease in total erythrocyte count (TEC), haemoglobin content (Hb) and packed cell volume (PCV), suggesting the occurrence of anaemia. Differential leucocyte count (DLC) showed a marked increase in the number of polymorphonuclear neutrophils. Saccharin toxicity, in terms of induction of haematological abnormalities in albino mice, is discussed.