+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hyperthermic response to intraventricular injection of scorpion venom: role of brain monoamines

Hyperthermic response to intraventricular injection of scorpion venom: role of brain monoamines

Toxicon 11(4): 361-368

Venom obtained from the scorpion Leiurus quinquestriatus produced a pronounced hyperthermic response when injected intraventricularly into rabbits. The venom-induced hyperthermia differed from that of pyrogens by its rapid onset following intraventricular injection and by the absence of the hyperthermic response when the venom was injected intravenously. The hyperthermic response was not antagonized by the prior intraventricular or intravenous injection of scorpion antiserum. Similarly, it was not modified by treatment with either chloropromazine or phenylbutazone. Pretreatment of rabbits with diethyldithio-carbamate or reserpine conferred partial protection against the hyperthermic response to the venom, whereas pretreatment of the rabbits with p-chlorophenylalanine markedly potentiated the response. Pretreatment of the rabbits with methysergide, tolazoline and/or propranolol did not modify the hyperthermic effect of the venom. The venom may act by releasing noradrenaline in the anterior hypothalamus or by causing, in the posterior hypothalamus, a shift in the balance of sodium and calcium.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 016052489

Download citation: RISBibTeXText

PMID: 4270842

DOI: 10.1016/0041-0101(73)90034-2

Related references

Hypothermic response to intracerebral injection of scorpion venom in rats: role of brain catecholamines. East African Medical Journal 51(9): 682-688, 1974

Characterization of a novel cDNA encoding a short venom peptide derived from venom gland of scorpion Buthus martensii Karsch: trans-splicing may play an important role in the diversification of scorpion venom peptides. Peptides 27(4): 675-681, 2005

Effect of intraventricular injection of somatostatin on pain threshold, and contents of the monoamines, xanthine, hypoxanthine in rats brain. Zhongguo Yao Li Xue Bao 12(6): 507-510, 1991

Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-Ala2-D-Leu5-enkephalin. Brain Research Bulletin 13(2): 263-268, 1984

Effects of intraventricular injection of 6-hydroxy-dopamine on the levels of monoamines and beta-endorphin in brain and serum TSH in the ground squirrel. Acta Zoologica Sinica 39(2): 169-175, 1993

Scorpion BmK venom induces nociceptive response of rats by plantar injection. Neurotoxicology and Teratology 23(6): 675-679, 2002

Hyperthermic effect of scorpion venom. Indian Journal of Pharmacology 26(1): 57-58, 1994

The subcellular distribution of some monoamines following their intraventricular injection into the rat. Canadian Journal of Biochemistry 52(4): 288-293, 1974

Effects of the intraventricular injection of 6-hydroxydopamine. I. On the cerebral monoamines of the cat. Brain Research 48: 281-293, 1972

Effects of intraventricular injection of 5,7-dihydroxytryptamine on monoamines and sleep in the kitten. Journal de Physiologie 77(2-3): 425-430, 1981

Effects of intraventricular injection of 6-hydroxydopamine on sleep states and cerebral monoamines in cats. Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 165(7): 1649-1653, 1971

Formaldehyde-induced fluorescence histochemistry of hypothalamus and neurohypophysis following intraventricular and intrahypothalamic injection of monoamines. Journal of Anatomy 110(Pt 3): 497, 1971

Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal. Bmc Genomics 10: 290, 2009

Extreme diversity of scorpion venom peptides and proteins revealed by transcriptomic analysis: implication for proteome evolution of scorpion venom arsenal. Journal of Proteomics 75(5): 1563-1576, 2012

Preparation of a potent anti-scorpion-venom-serum against the venom of red scorpion (Buthus tamalus). Journal of Postgraduate Medicine 44(4): 85-92, 2000