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Locomotor bone strain as the stimulus for bone's mechanical adaptability

Journal of Physiology 245(2): 57p-57p

Locomotor bone strain as the stimulus for bone's mechanical adaptability

Accession: 016288990

PMID: 1142191

Related references

Lanyon L.E., 1991: Biomechanical properties of bone and response of bone to mechanical stimuli functional strain as a controlling influence on bone modeling and remodeling behavior. Hall, B K (Ed ) Bone, Vol 3 Bone Matrix And Bone Specific Products Ix+333p Crc Press, Inc : Boca Raton, Florida, Usa; London, England, Uk Illus 79-108

Lanyon L.E., 1987: Functional strain in bone tissue as an objective and controlling stimulus for adaptive bone remodelling. The skeleton consists of a series of elements with a variety of functions. In locations where shape or protection are of prime importance the bone's architecture is achieved during growth under direct genetic control. In locations where resis...

Meissner, E., 1968: Action and reaction of bone to functional mechanical stimulus (behavior of bone tissue exposed to orthodontic and prosthetic appliances). Revista Odontologica de Concepcion 13(1): 29-39

Pitsillides, A.A.; Rawlinson, S.C.; Suswillo, R.F.; Bourrin, S.; Zaman, G.; Lanyon, L.E., 1995: Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling?. To investigate the role of nitric oxide (NO) in the response of bone to load induced strains, cultured rat long bone derived osteoblast-like cells and embryonic chick osteocytes were used. Transient rapid increases in NO release were stimulated by...

Rubin, C.; Turner, A.S.; Mallinckrodt, C.; Jerome, C.; Mcleod, K.; Bain, S., 2002: Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone. Departing from the premise that it is the large-amplitude signals inherent to intense functional activity that define bone morphology, we propose that it is the far lower magnitude, high-frequency mechanical signals that continually barrage the sk...

David, V.; Guignandon, A.; Martin, A.; Malaval, L.; Lafage-Proust, M-Hélène.; Rattner, A.; Mann, V.; Noble, B.; Jones, D.B.; Vico, L., 2008: Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain. Our aim was to test cell and trabecular responses to mechanical loading in vitro in a tissue bone explant culture model. We used a new three-dimensional culture model, the ZetOS (TM) system, which provides the ability to exert cyclic compression...

Westerlind, K.C.; Wronski, T.J.; Ritman, E.L.; Luo,; An, K.N.n; Bell, N.H.; Turner, R.T., 1997: Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain. Estrogen deficiency induced bone loss is associated with increased bone turnover in rats and humans. The respective roles of increased bone turnover and altered balance between bone formation and bone resorption in mediating estrogen deficiency-in...

Qi, M-chun.; Zou, S-juan.; Han, L-chi.; Zhou, H-xiao.; Hu, J., 2010: Expression of bone-related genes in bone marrow MSCs after cyclic mechanical strain: implications for distraction osteogenesis. Understanding the response of mesenchymal stem cells (MSCs) to mechanical strain and their consequent gene expression patterns will broaden our knowledge of the mechanobiology of distraction osteogenesis. In this study, a single period of cyclic m...

Saito, M.; Marumo, K., 2010: Musculoskeletal rehabilitation and bone. Mechanical stress and bone quality : do mechanical stimuli alter collagen cross-link formation in bone? "Yes". Evidence has accumulated that collagen cross-links also play important roles in bone strength and the proper biological functions of bone. Thus, collagen cross-links may be a factor in determining the material properties of bone. Collagen cross-li...

Jing, D.; Luo, E.; Cai, J.; Tong, S.; Zhai, M.; Shen, G.; Wang, X.; Luo, Z., 2016: Mechanical Vibration Mitigates the Decrease of Bone Quantity and Bone Quality of Leptin Receptor-Deficient Db/Db Mice by Promoting Bone Formation and Inhibiting Bone Resorption. Leptin, a major hormonal product of adipocytes, is involved in regulating appetite and energy metabolism. Substantial studies have revealed the anabolic actions of leptin on skeletons and bone cells both in vivo and in vitro. Growing evidence has...