EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Period prevalence of abnormal glucose tolerance and cardiovascular risk factors among obese children attending an obesity centre in Italy



Period prevalence of abnormal glucose tolerance and cardiovascular risk factors among obese children attending an obesity centre in Italy



Nutrition, Metabolism, and Cardiovascular Diseases 16(4): 256-262



Background and aim: Several reports have described an increasing prevalence and incidence of type 2 diabetes among children. Limited information is available about the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes in obese children, particularly in Europe. The aim of this study was to examine the prevalence of glucose intolerance and other cardiovascular risk factors in obese children over a 24-year period. Methods and results: The study population consisted of 1376 consecutive subjects who attended a national centre for the study of obesity between 1979 and 2002. Subjects were divided into three successive 8-year cohorts: cohort 1 (period 1979-1986, n=453, male: 39%), cohort 2 (period 1987-1994, n=409, male: 46%), cohort 3 (period 1995-2002, n=514, male: 48%). All subjects underwent an oral glucose tolerance test. Lipids, blood pressure, uric acid, C-reactive protein (CRP), fasting insulin and birth weight were recorded. Insulin resistance was measured by homeostasis model assessment (HOMA-IR). The degree of obesity was higher in the more recent cohorts (standard deviation score of body mass index: 3.3+or-0.04 vs. 3.7+or-0.04 vs. 3.8+or-0.03, P<0.0001). The proportion of subjects with glucose intolerance was lower in the last two cohorts compared with the first one (11.2% vs. 3.9% vs. 6.0%, P<0.0001). This was predominantly due to changes in the frequency of IGT (9.1% vs. 3.2% vs. 5.4%, P<0.001 in cohorts 1, 2 and 3, respectively) while the prevalence of undiagnosed type 2 diabetes and impaired fasting glucose was similar in the three cohorts (0.9% vs. 0% vs. 0.2% and 1.3% vs. 0.7% vs. 0.4%, respectively). After adjustment for differences in age, sex, pubertal status and birth weight the levels of fasting insulin, HOMA-IR, total cholesterol, triglycerides and blood pressure, were significantly lower in cohorts 2 and 3 than in cohort 1 while CRP and uric acid were higher in the last two cohorts. Conclusion: Over a recent period spanning 24 years, the degree of obesity has risen but the prevalence of glucose intolerance has fallen in obese children admitted to an obesity centre. This was accompanied by an improvement in traditional but a worsening in non-traditional risk factors for cardiovascular disease.

(PDF emailed within 0-6 h: $19.90)

Accession: 016630999

Download citation: RISBibTeXText

PMID: 16679217

DOI: 10.1016/j.numecd.2005.10.001



Related references

Glucose tolerance status in 510 children and adolescents attending an obesity clinic in Central Italy. Pediatric Diabetes 11(1): 47-54, 2010

Increased prevalence of abnormal glucose tolerance among obese siblings of children with type 2 diabetes. Journal of Pediatrics 154(4): 562-566.E1, 2008

Association of obesity and distribution of obesity with glucose tolerance and cardiovascular risk factors in the elderly. International Journal of Obesity and Related Metabolic Disorders 16(9): 695-704, 1992

Japanese Americans classified as having normal fasting glucose may have abnormal glucose tolerance and cardiovascular disease risk factors. Journal of Investigative Medicine 48(1): 21A, January, 2000

Prevalence of abnormal oral glucose tolerance with concomitant dyslipidaemia: implications for cardiovascular risk assessment in prediabetes. British Journal of Biomedical Science 69(3): 97-98, 2012

Prevalence of abnormal glucose tolerance and risk factors in urban and rural Malaysia. Diabetes Care 34(6): 1362-1364, 2011

Abnormal glucose tolerance in chronic hepatitis B and C in Greece Prevalence and risk factors. Hepatology 34(4 Pt 2): 573A, October, 2001

The prevalence of cardiovascular risk factors in obese children. Irish Medical Journal 108(5): 134-136, 2015

Effect of body mass reduction in obese patients with abnormal glucose tolerance and diabetes on selected arteriosclerosis risk factors. Polski Tygodnik Lekarski 37(19-20): 559-563, 1982

Risk factors associated with abnormal glucose tolerance in the early postpartum period among Japanese women with gestational diabetes. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics 129(1): 42-45, 2015

Risk factors for impaired glucose tolerance in obese children and adolescents. World Journal of Diabetes 1(4): 129-134, 2011

Cardiovascular risk factors in newly diagnosed abnormal glucose tolerance: Comparison of 1997 ADA and 1985 WHO criteria. Diabetologia 42(10): 1268-1269, 1999

A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia 56(4): 714-723, 2013

Prevalence of unrecognized abnormal glucose tolerance in patients attending a hospital hypertension clinic. American Journal of Hypertension 17(6): 483-488, 2004