+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Regulation of innate immune response by MAP kinase phosphatase-1

Regulation of innate immune response by MAP kinase phosphatase-1

Cellular Signalling 19(7): 1372-1382

Mitogen-activated protein (MAP) kinase cascades are signal transduction pathways that play pivotal regulatory roles in the biosynthesis of pro-inflammatory cytokines. MAP kinase phosphatase (MKP)-1, an archetypal member of the MKP family, is essential for the dephosphorylation/deactivation of MAP kinases p38 and JNK. Earlier studies conducted using cultured immortalized macrophages provided compelling evidence indicating that MKP-1 deactivates p38 and JNK, thereby limiting pro-inflammatory cytokine biosynthesis in innate immune cells exposed to microbial components. Recent studies employing MKP-1 knockout mice have confirmed the central function of MKP-1 in the feedback control of p38 and JNK activity as well as the crucial physiological function of MKP-1 as a negative regulator of the synthesis of pro-inflammatory cytokines in vivo. MKP-1 was shown to be a major feedback regulator of the innate immune response and to play a critical role in preventing septic shock and multi-organ dysfunction during pathogenic infection. In this review, we will update the studies on the biochemical properties and the regulation of MKP-1, and summarize our understanding on the physiological function of this key phosphatase in the innate immune response.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 016878988

Download citation: RISBibTeXText

PMID: 17512700

DOI: 10.1016/j.cellsig.2007.03.013

Related references

MAP kinase phosphatase-1, a critical negative regulator of the innate immune response. International Journal of Clinical and Experimental Medicine 2(1): 48-67, 2009

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. Journal of Experimental Medicine 203(1): 131-140, 2005

Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ. Plos One 9(2): E89284-E89284, 2015

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proceedings of the National Academy of Sciences of the United States of America 103(7): 2274-2279, 2006

The role of Toll-like receptors (TLR) in innate and adaptive immune responses and their function in immune response regulation. Postepy Higieny i Medycyny Doswiadczalnej 60: 52-63, 2006

Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1. Journal of Leukocyte Biology 95(4): 651-659, 2014

Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response. Clinical Immunology 138(3): 299-310, 2011

The antibacterial arm of the Drosophila innate immune response requires an IkB kinase. Genes and Development 15(1): 4-10, 2001

Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1. European Journal of Immunology 35(6): 1906-1917, 2005

The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase. Genes & Development 15(1): 104-110, 2001

c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response. Febs Letters 584(1): 33-38, 2010

Novel Role of TRPML2 in the Regulation of the Innate Immune Response. Journal of Immunology 195(10): 4922-4932, 2016

Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1. European Journal of Immunology 35(12): 3405-3413, 2005

Regulation of receptor-dependent activation of the innate immune response. Journal of Infectious Diseases 187 Suppl 2: S351-S355, 2003

Regulation of the innate immune response by fibronectin: synergism between the III-1 and EDA domains. Plos One 9(7): E102974-E102974, 2015