+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Respiratory infections for which general practitioners consider prescribing an antibiotic: a prospective study



Respiratory infections for which general practitioners consider prescribing an antibiotic: a prospective study



Archives of Disease in Childhood 92(7): 594-597



To determine the viral aetiology of respiratory infections in children presenting to primary care with "more than a simple cold". Observational study in 18 Oxfordshire general practices over four winters (2000-01 to 2003-04). 425 children aged 6 months to 12 years with cough and fever for whom general practitioners considered prescribing an antibiotic. Nasopharyngeal aspirate obtained from 408 (96%) children was subjected to PCR for respiratory viruses. Parents completed an illness diary for the duration of illness. A viral cause of infection was detected in most (77%) children. Clinical symptoms correctly identified the infecting virus in 45% of cases. The duration of illness was short and the time course was very similar for all infecting viruses. One third of children were prescribed an antibiotic (34%), but this made no difference to the rate of parent-assessed recovery (Kruskal-Wallis, p = 0.67). About one in five children with influenza who did not receive an antibiotic had persistent fever on day 7 compared to no children receiving antibiotics (p = 0.02); this difference remained after adjustment for severity and other factors and was not seen with other viruses. Most children receiving antibiotics for respiratory symptoms in general practice have an identifiable viral illness. In routine clinical practice, neither the specific infecting virus nor the use of antibiotics has a significant effect on the time course of illness. Antibiotics may reduce the duration of fever in children with influenza which could reflect an increased risk of secondary bacterial infection for such children.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 016922139

Download citation: RISBibTeXText

PMID: 17369279

DOI: 10.1136/adc.2007.116665


Related references

Reducing early career general practitioners' antibiotic prescribing for respiratory tract infections: a pragmatic prospective non-randomised controlled trial. Family Practice 35(1): 53-60, 2018

Enabling factors for antibiotic prescribing for upper respiratory tract infections: perspectives of Lithuanian and Russian general practitioners. Upsala Journal of Medical Sciences 118(2): 98, 2013

Prescribing habits of general practitioners in choosing an empirical antibiotic regimen for lower respiratory tract infections in adults in Sicily. Pharmacological Research 40(1): 47-52, 1999

Antibiotic prescribing decisions for acute respiratory illness When and which? A study of 211 general practitioners and 113 hospital doctors. Thorax 55(Suppl. 3): A11, 2000

Antibiotic treatment failure when consulting patients with respiratory tract infections in general practice. A qualitative study to explore Danish general practitioners' perspectives. European Journal of General Practice 23(1): 120-127, 2017

Respiratory tract infections in general practice: considerable differences in prescribing habits between general practitioners in Denmark and Spain. European Journal of Clinical Pharmacology 60(1): 23-28, 2004

Antibiotic Prescribing by Physicians Versus Nurse Practitioners for Pediatric Upper Respiratory Infections. Annals of Otology Rhinology and Laryngology 125(12): 982-991, 2016

Prescribing habits of general practitioners in the treatment of childhood respiratory-tract infections. European Journal of Clinical Pharmacology 60(3): 211-216, 2004

Antibiotic prescribing for respiratory tract infections in general practice. Pharmacoepidemiology and Drug Safety 8(2): 95, 1999

Antibiotic prescribing in acute respiratory tract infections in general practice. Anales de Pediatria 82(6): 412-416, 2015

Do general practitioners' consultation rates influence their prescribing patterns of antibiotics for acute respiratory tract infections?. Journal of Antimicrobial ChemoTherapy 66(10): 2425-2433, 2011

Improving antibiotic prescribing in acute respiratory tract infections: cluster randomised trial from Norwegian general practice (prescription peer academic detailing (Rx-PAD) study). Bmj 347: F4403, 2013

An investigation of antibiotic prescribing by general dental practitioners: a pilot study. Primary Dental Care 5(1): 11-14, 1998

Antibiotic prescribing behavior among general practitioners - a questionnaire-based study in Germany. Bmc Infectious Diseases 18(1): 208, 2018

Differences in antibiotic prescribing patterns between general practitioners in Scandinavia: a questionnaire study. Scandinavian Journal of Infectious Diseases 34(8): 602-609, 2002