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Severe upper-GI bleeding in a patient with PEG tube placement by the radiologic push method



Severe upper-GI bleeding in a patient with PEG tube placement by the radiologic push method



Gastrointestinal Endoscopy 65(6): 935-937



Loop flexibility is discussed as a factor that affects ligand binding affinity of SH3 domains. To test this hypothesis, we designed a mutant in which a proline in the RT-loop of the human Lck SH3-domain is replaced by glycine. The dynamics and ligand binding properties of wild-type and mutant LckSH3 were studied by fluorescence and NMR spectroscopy as well as molecular dynamics simulations.

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Accession: 017022313

Download citation: RISBibTeXText

PMID: 17382941

DOI: 10.1016/j.gie.2006.09.019


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