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Some in vivo and in vitro studies of the aqueous leaf extract of Phyllanthus muellerianus (Euphorbiaceae) in laboratory animals



Some in vivo and in vitro studies of the aqueous leaf extract of Phyllanthus muellerianus (Euphorbiaceae) in laboratory animals



Journal of Pharmacy and Bioresources 2(2): 93-99



The aqueous leaf extract of Phyllanthus muellerianus (5-30 mg/kg, ip) was found to induce behavioural sedation/sleep in young chicks (2-day old) resulting in decreased locomotor activity as well as pecking behaviour. The extract (0.16-1.4 mg/ml) relaxed the rabbit and rat ilea with the rabbit ileum being more responsive. The effect of the extract on rat ileum was antagonized mainly by propranolol and to a lesser extent by phenoxybenzamine (0.16 micro g/ml).

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