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The administration of maleic hydrazide and its diethanolamine salt to rats



The administration of maleic hydrazide and its diethanolamine salt to rats



Toxicology 1(4): 301-307



Groups each of 25 male and 25 female rats from a closed outbred Wistar Colony were injected subcutaneously with 2 mg of either maleic hydrazide (MH) or of its diethanolamine derivative (MH30), in either arachis oil or water, twice weekly for 65 weeks, and the animals maintained under observation for a further 39 weeks. In the group receiving MH in arachis oil there were 4 subcutaneous tumours, compared with 1 in the control group receiving arachis oil alone. There was no significant elevation of tumour incidence in rats receiving MH in water, or MH30 in either arachis oil or water, and none of the treatments appeared to affect the incidence of hepatic or mammary gland tumours.

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Accession: 017305485

Download citation: RISBibTeXText

PMID: 4781151

DOI: 10.1016/0300-483x(73)90036-x


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