+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The selective dopamine D3 receptor antagonists, SB 277011-A and S 33084 block haloperidol-induced catalepsy in rats



The selective dopamine D3 receptor antagonists, SB 277011-A and S 33084 block haloperidol-induced catalepsy in rats



European Journal of Pharmacology 572(2-3): 171-174



SB 277011-A (trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide) and S 33084 [(3aR,9bS)-N[4-(8-cyano-1,3a,4,9b-tetrahydro-3H-benzopyrano[3,4-c]pyrrole-2-yl)-butyl](4-phenyl)benzamide] were already shown to lack cataleptogenic actions. Further to that, we report that SB 277011 exerted a dose-dependent dampening on the development of haloperidol-induced catalepsy in the dose-range of 13.5-30 mg/kg p.o. while S 33084, at the dose of 0.625 mg/kg sc. significantly inhibited catalepsy induced by haloperidol; had no effect at 1.25 mg/kg, and further augmented the effect of haloperidol after 2.5 mg/kg. The compounds also produced effective inhibition when administered 2 hours after haloperidol. The results underline that dopamine D3 receptor antagonist action may have therapeutic value in the treatment of schizophrenia.

(PDF emailed within 0-6 h: $19.90)

Accession: 017475847

Download citation: RISBibTeXText

PMID: 17628535

DOI: 10.1016/j.ejphar.2007.06.035


Related references

Reduced expression of haloperidol conditioned catalepsy in rats by the dopamine D3 receptor antagonists nafadotride and NGB 294. 2012

Reduced expression of haloperidol conditioned catalepsy in rats by the dopamine D3 receptor antagonists nafadotride and NGB 2904. European Neuropsychopharmacology 22(10): 761-768, 2013

5Ht2-receptor antagonists can attenuate submaximal haloperidol-induced catalepsy in rats. Schizophrenia Research 15(1-2): 153-154, 1995

Effect of M3-choline receptor blockade on the ability of muscarinic antagonists to prevent catalepsy induced by haloperidol in rats. Eksperimental'naia i Klinicheskaia Farmakologiia 64(4): 10-12, 2001

Selective d 1 and d 2 dopamine receptor antagonists similar profiles in catalepsy and supersensitive locomotor testing in rats. Society for Neuroscience Abstracts 12(2): 1137, 1986

A selective D3 dopamine receptor antagonist, SB-277011-A, alters activity of midbrain dopamine neurons in rats. Society for Neuroscience Abstracts 27(2): 1764, 2001

Haloperidol-induced catalepsy is absent in dopamine D2, but maintained in dopamine D3 receptor knock-out mice. European Journal of Pharmacology 391(1-2): 63-73, March 10, 2000

Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat. Journal of Sexual Medicine 6(4): 980-988, 2009

Haloperidol-induced catalepsy is influenced by adenosine receptor antagonists. Polish Journal of Pharmacology 49(5): 323-327, 1998

5-HT2c receptor antagonists, but not a 5-HT2A or 5-HT2B receptor antagonist, attenuate haloperidol-induced catalepsy in rat. British Journal of Pharmacology 125(PROC SUPPL ): 65P, 1998

Catalepsy-associated behavior induced by dopamine D1 receptor antagonists and partial dopamine D1 receptor agonists in squirrel monkeys. European Journal of Pharmacology 260(2-3): 237-241, 1994

NMDA receptor antagonists inhibit catalepsy induced by either dopamine D-1 or D-2 receptor antagonists. European Journal Of Pharmacology. 237(1): 1-7, 1993

SB - 277011 - A, a selective dopamine D3 receptor antagonist, reduces cocaine - seeking behavior in response to drug - associated stimuli in rats. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 420 3, 2003

Effects of dopamine agonistic and anticholinergic agents on catalepsy induced by d 1 d 2 and d 1 d 2 dopamine antagonists in rats. Japanese Journal of Pharmacology 46(SUPPL): 169P, 1988

Effects of postsynaptic dopamine receptor upregulation on haloperidol induced catalepsy in mice. Japanese Journal of Pharmacology 52(SUPPL 1): 173P, 1990