Toxicity of methylmercury on the maintenance of human brain microvascular endothelial cells in culture

Hirooka, T.; Fujiwara, Y.; Yamamoto, C.; Yasutake, A.; Kaji, T.

Yakugaku Zasshi 127(Suppl 1): 37


ISSN/ISBN: 0031-6903
Accession: 017537846

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Methylmercury (MeHg) is an environmental pollutant that causes severe neuropathy in the brain of exposed humans and animals. In the present study, we suggest that MeHg exhibits toxicity in the brain microvessels when the endothelial monolayer is damaged. MeHg specifically inhibits the proliferation of cultured human brain microvascular endothelial cells during the repair process of the damaged monolayers. The present data support the hypothesis that the mechanism of MeHg-induced neuropathy in the brain includes changes in the microenvironment of the neurons caused by functional damage to the microvessels.