Section 18
Chapter 17,619

Using public health indicators to measure the success of hypertension control

Cooper, R.S.

Hypertension 49(4): 773-774


ISSN/ISBN: 0194-911X
PMID: 17309956
DOI: 10.1161/01.hyp.0000259106.77783.f8
Accession: 017618353

The nitroxyl anion (HNO) is emerging as a novel regulator of cardiovascular function with therapeutic potential in the treatment of diseases such as heart failure. It remains unknown whether tolerance develops to HNO donors, a limitation of currently used nitrovasodilators. The susceptibility of the HNO donor, Angeli's salt (AS), to the development of vascular tolerance was compared with the NO donors, glyceryl trinitrate (GTN) and diethylamine/NONOate (DEA/NO) in rat isolated aortae.

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