Section 18
Chapter 17,776

Application of 1H-nuclear magnetic resonance spectroscopic method for quinidine to simultaneous determination of quinidine and dihydroquinidine in quinidine sulfate tablets

Hanna, G.M.; Lau-Cam, C.A.

Journal - Association of Official Analytical Chemists 71(6): 1118-1121


ISSN/ISBN: 0004-5756
PMID: 3240964
Accession: 017775349

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Based on the structural differences between quinidine and dihydroquinidine, a 1H-nuclear magnetic resonance spectroscopic method previously reported for quinidine drug substance was modified and shown to be applicable to the quantitative determination of both compounds in quinidine sulfate tablets. Deuterated chloroform was used as the solvent and hexamethylcyclotrisiloxane served as an internal standard. The average recovery and standard deviation of quinidine sulfate (calculated as the sum of quinidine sulfate plus dihydroquinidine sulfate) from synthetic formulations was 98.94 +/- 0.43% (n = 10). Five lots of 200 mg tablets of quinidine sulfate from one commercial source were found to contain from 92.9 to 95.8% quinidine sulfate, and from 1.1 to 7.0% dihydroquinidine sulfate.

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