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Biography of George E. Andrews

Biography of George E. Andrews

Proceedings of the National Academy of Sciences of the United States of America 102(13): 4663-4665

S100B protein is elevated in the brains of patients with early stages of Alzheimer's disease and Down's syndrome. S100A4 is correlated with the development of metastasis. Both proteins bind to p53 tumor suppressor. We found that both S100B and S100A4 bind to the tetramerization domain of p53 (residues 325-355) only when exposed in lower oligomerization states and so they disrupt the tetramerization of p53.

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Accession: 017790019

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PMID: 15781855

DOI: 10.1073/pnas.0501311102

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