+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations

CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations

Journal of Immunology 165(6): 3105-3110

Previously we have shown that autoimmune diabetes, induced in rats by a protocol of adult thymectomy and split-dose gamma irradiation, can be prevented by the transfer of a subset of CD4+ T cells with a memory phenotype (CD45RC-), as well as by CD4+CD8- thymocytes, from syngeneic donors. Further studies now reveal that in the thymus the regulatory cells are observed in the CD25+ subset of CD4+CD8- cells, whereas transfer of the corresponding CD25- thymocyte subset leads to acceleration of disease onset in prediabetic recipients. However, in the periphery, not all regulatory T cells were found to be CD25+. In thoracic duct lymph, cells that could prevent diabetes were found in both CD25- and CD25+ subsets of CD4+CD45RC- cells. Further, CD25- regulatory T cells were also present within the CD4+CD45RC- cell subset from spleen and lymph nodes, but were effective in preventing diabetes only after the removal of CD25- recent thymic emigrants. Phenotypic analysis of human thymocytes showed the presence of CD25+ cells in the same proportions as in rat thymus. The possible developmental relationship between CD25+ and CD25- regulatory T cells is discussed.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 017797995

Download citation: RISBibTeXText

PMID: 10975823

DOI: 10.4049/jimmunol.165.6.3105

Related references

CD25 is a marker for thymocytes and peripheral T cells that prevent autoimmune diabetes in rats. Immunology 98(Suppl 1): 36, 1999

Follicular lymphoma intratumoral CD4+CD25+GITR+ regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8+CD25- and CD4+CD25- T cells. Journal of Immunology 178(7): 4051-4061, 2007

Il-4 Has Tolerogenic And Allogenic Effects: It Activates Cd4+Cd25+ T Cells To Induce Specific Transplant Tolerance And Promotes Rejection, Effecting Cd4+Cd25-T Cells To Express Cd25 But Not Foxp3. Transplantation 86(Suppl.): 513-514, 2008

CD25-positive cells during pregnancy: Differential profile of cytokines and soluble MHC antigens produced by CD25+CD4+ and CD25+CD8+ cells. Journal of Reproductive Immunology 71(2): 173-0, 2006

T cell receptor beta chain (TCR-Vbeta) repertoire of circulating CD4(+) CD25(-), CD4(+) CD25(low) and CD4(+) CD25(high) T cells in patients with long-term renal allograft survival. Transplant International 23(1): 54-63, 2010

Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood 102(12): 4107-4114, 2003

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells. International Immunology 18(11): 1607-1613, 2006

CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Foundation Symposium 252: 67-88; Discussion 88-91 106-14, 2003

Analysis of frequency of peripheral blood CD4+; CD25(high);Tregs and CD4+; CD25(low);T cells and expression of PD-1 in SLE and RA patients. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27(1): 23-25, 2011

Increased Numbers of CD4 + CD25 + and CD8 + CD25 + T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection. In Vivo 31(2): 181-185, 2017

High cell surface expression of CD4 allows distinction of CD4(+)CD25(+) antigen-specific effector T cells from CD4(+)CD25(+) regulatoiy T cells in murine experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 192(1-2): 57-67, 2007

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. Journal of Experimental Medicine 198(12): 1875-1886, 2003

Conversion of peripheral CD4(+) CD25(-) naive T cells to CD4(+) CD25(+) regulatory T cells by ovarian carcinoma cell supernatants. Zhonghua Weishengwuxue He Mianyixue Zazhi 26(2): 121-124, 2006

Conversion of peripheral CD4(+)CD25(-) T cells to CD4(+)CD25(+) regulatory T cells by IFN-gamma in patients with Guillain-Barré syndrome. Journal of Neuroimmunology 217(1-2): 80-84, 2009

Control of autoimmune myocarditis and multiorgan inflammation by glucocorticoid-induced TNF receptor family-related protein(high), Foxp3-expressing CD25+ and CD25- regulatory T cells. Journal of Immunology 176(8): 4748-4756, 2006