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Discovery of a new pyrimidine dimer in bacteriophage T4 DNA






BioScience 33: 7-18

Discovery of a new pyrimidine dimer in bacteriophage T4 DNA



Accession: 017858420

DOI: 10.2307/1309145



Related references

Saporito, S.M.; Gedenk, M.; Cunningham, R.P., 1989: Role of exonuclease III and endonuclease IV in repair of pyrimidine dimers initiated by bacteriophage T4 pyrimidine dimer-DNA glycosylase. The role of exonuclease III and endonuclease IV in the repair of pyrimidine dimers in bacteriophage T4-infected Escherichia coli was examined. UV-irradiated T4 showed reduced survival when plated on an xth nfo double mutant but showed wild-type su...

Tsujimoto M.; Katayanagi K.; Matsushima M.; Ikehara M.; Inaoka T.; Ohtsuka E.; Morikawa K., 1990: Structures of pyrimidine dimer specific excision repair enzyme bacteriophage t4. Protein Engineering 3(4): 326-327

Tateishi, S.; Hori, N.; Ohtsuka, E.; Yamaizumi, M., 1993: Human nucleotide excision nuclease incises synthetic double-stranded DNA containing a pyrimidine dimer at the fourth phosphodiester linkage 3' to the pyrimidine dimer. Linear 75mer double-stranded DNA containing a single pyrimidine dimer at a unique site was used to investigate pyrimidine dimer-dependent endonuclease activities from human cells. HeLaS3 cell extract incised the target DNA at the fourth phosphodie...

Tateishi, S.; Hori, N.; Ohtsuka, E.; Yamaizumi, M., 1993: Human nucleotide excision nuclease incises synthetic double-stranded DNA containing a pyrimidine dimer at the fourth phosphodiester linkage 3' to the pyrimidine dimer. Linear 75mer double-stranded DNA containing a single pyrimidine dimer at a unique site was used to investigate pyrimidine dimer-dependent endonuclease activities from human cells. HeLaS3 cell extract incised the target DNA at the fourth phosphodie...

McMillan, S.; Edenberg, H.J.; Radany, E.H.; Friedberg, R.C.; Friedberg, E.C., 1981: den V gene of bacteriophage T4 codes for both pyrimidine dimer-DNA glycosylase and apyrimidinic endonuclease activities. Recent studies have shown purified preparations of phage T4 UV DNA-incising activity (T4 UV endonuclease or endonuclease V of phage T4) contain a pyrimidine dimer-DNA glycosylase activity that catalyzes hydrolysis of the 5' glycosyl bond of d...

Bonura, T.; Radany, E.H.; McMillan, S.; Love, J.D.; Schultz, R.A.; Edenberg, H.J.; Friedberg, E.C., 1982: Pyrimidine dimer-DNA glycosylases: studies on bacteriophage T4-infected and on uninfected Escherichia coli. Pyrimidine dimer (PD)-DNA glycosylase activity has been reported in both the M. luteus and phage T4 UV endonucleases. In the present studies the T4 PD-DNA glycosylase has been purified close to physical homogeneity using an assay that measures the...

Morikawa, K.; Matsumoto, O.; Tsujimoto, M.; Katayanagi, K.; Doi, T.; Ariyoshi, M.; Ikehara, M.; Inaoka, T.; Ohtsuka, E., 1991: Atomic structure of a pyrimidine-dimer specific excision-repair enzyme from bacteriophage T4. T4 endonuclease V is an enzyme responsible for the first step of a pyrimidine-dimer specific excision-repair process. The three-dimensional structure of this enzyme has been determined at 1.6A resolution by X-ray crystallography. The enzyme consis...

Friedberg, E.C.; Ganesan, A.K.; Seawell, P.C., 1980: Purification and properties of a pyrimidine dimer-specific endonuclease from E. coli infected with bacteriophage T4. Methods in Enzymology 65(1): 191-201

Kurosaki, Y.; Abe, H.; Morioka, H.; Hirayama, J.; Ikebuchi, K.; Kamo, N.; Nikaido, O.; Azuma, H.; Ikeda, H., 2003: Pyrimidine dimer formation and oxidative damage in M13 bacteriophage inactivation by ultraviolet C irradiation. The mechanism by which UV-C irradiation inactivates M13 bacteriophage was studied by analyzing the M13 genome using agarose gel electrophoresis and South-Western blotting for pyrimidine dimers. The involvement of singlet oxygen (1O2) was also inve...

Morikawa, K.; Tsujimoto, M.; Ikehara, M.; Inaoka, T.; Ohtsuka, E., 1988: Preliminary crystallographic study of pyrimidine dimer-specific excision-repair enzyme from bacteriophage T4. Bacteriophage T4 endonuclease V, which is an excision-repair enzyme specific to pyrimidine dimers within DNA, has been crystallized from polyethylene glycol 4000 solution by a vapour diffusion technique. The unit cell is monoclinic, space group P2...