EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of a single breath of 100% oxygen on respiration in neonates during sleep



Effect of a single breath of 100% oxygen on respiration in neonates during sleep



Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 57(5): 1531-1535



To determine the effect of a single breath of 100% O2 on ventilation, 10 full-term [body wt 3,360 +/- 110 (SE) g, gestational age 39 +/- 0.4 wk, postnatal age 3 +/- 0.6 days] and 10 preterm neonates (body wt 2,020 +/- 60 g, gestational age 34 +/- 2 wk, postnatal age 9 +/- 2 days) were studied during active and quiet sleep states. The single-breath method was used to measure peripheral chemoreceptor response. To enhance response and standardize the control period for all infants, fractional inspired O2 concentration was adjusted to 16 +/- 0.6% for a control O2 saturation of 83 +/- 1%. After 1 min of control in each sleep state, each infant was given a single breath of O2 followed by 21% O2. Minute ventilation (VE), tidal volume (VT), breathing frequency (f), alveolar O2 and CO2 tension, O2 saturation (ear oximeter), and transcutaneous O2 tension were measured. VE always decreased with inhalation of O2 (P less than 0.01). In quiet sleep, the decrease in VE was less in full-term (14%) than in preterm (40%) infants (P less than 0.001). Decrease in VE was due primarily to a drop in VT in full-term infants as opposed to a fall in f and VT in preterm infants (P less than 0.05). Apnea, as part of the response, was more prevalent in preterm than in full-term infants. In active sleep the decrease in VE was similar both among full-term (19%) and preterm (21%) infants (P greater than 0.5). These results suggest greater peripheral chemoreceptor response in preterm than in full-term infants, reflected by a more pronounced decrease in VE with O2. The results are compatible with a more powerful peripheral chemoreceptor contribution to breathing in preterm than in full-term infants.

(PDF same-day service: $19.90)

Accession: 017870437

Download citation: RISBibTeXText

PMID: 6520049

DOI: 10.1203/00006450-198404001-01500



Related references

Effect of a single breath of 100 percent oxygen on respiration in neonates during sleep. Journal of Applied Physiology Respiratory Environmental & Exercise Physiology 57(5): 1531-1535, 1984

The effect of a single breath of oxygen on respiration in the newborn lamb. Respiration Physiology 1(3): 297-307, 1966

Single breath induction of anaesthesia, using a vital capacity breath of halothane, nitrous oxide and oxygen. Anaesthesia 41(5): 472-476, 1986

The effect of a single breath of 100% oxygen on breathing in infants at 1, 2, and 3 months of age. American Review of Respiratory Disease 144(1): 141-145, 1991

The effect of a single breath of 100 percent oxygen on breathing in infants at 1 2 and 3 months of age. American Review of Respiratory Disease 144(1): 141-145, 1991

Effect of posture on the single-breath oxygen test in normal subjects. Journal of Applied Physiology 41(4): 474-479, 1976

The effect of oxygen on respiration and sleep in patients with congestive heart failure. Annals of Internal Medicine 111(10): 777-782, 1989

A new single-breath spirometer for neonates. Anesthesia and Analgesia 48(6): 923-927, 1969

Effect of oxygen concentration on single breath carbon monoxide diffusing capacity variability. Chest 89(6 SUPPL): 488S, 1986

The single breath distribution index single breath to multiple breath total lung capacity ratio in chronic bronchitis and emphysema. Bulletin de Physio-Pathologie Respiratoire 10(1): 39-49, 1974

Oxygen and reduced umbilical blood flow trigger the first breath of human neonates. Acta Paediatrica Japonica 34(6): 660-662, 1992

Effect of oxygen on sleep, cognitive function and sympathetic activity in heart failure with Cheyne-Stokes respiration. Journal of the American College of Cardiology 31(2 SUPPL A): 250A, 1998

The single breath test in neonates: does pressurization of the pneumotachograph make a difference?. Pediatric Pulmonology 19(5): 299-306, 1995

Single breath CO measurements normalized to 5% CO2 in Coombs' test positive neonates. Physiological Measurement 28(9): 977-988, 2007

Single breath inhalation of oxygen for estimating regional oxygen consumption in human hearts via PET. Journal of Nuclear Medicine 37(5 SUPPL ): 146P-147P, 1996