+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Effect of antibiotic treatment on receptivity of uroepithelial cells to uropathogens

Effect of antibiotic treatment on receptivity of uroepithelial cells to uropathogens

Canadian Journal of Microbiology 34(3): 327-331

The management of female patients with recurrent urinary tract infections still remains a problem, and long-term prophylactic or short intermittent courses of antibiotics are the standard forms of therapy. In this report, 10 patients were examined for the effects of long- and short-term treatment with trimethoprim-sulfamethoxazole (TMP-SMX) antibiotics on the receptivity of uroepithelial cells to bacterial adherence. The urine of all patients was sterile while on antibiotic therapy. Few bacteria were found adherent to the cells from adult patients (group 1, mean age 36 years) on long-term antibiotics, but the cells were highly receptive to uropathogens in vitro, especially for Escherichia coli expressing mannose-resistant adhesins. Controls of age-matched adult females were included and in vitro adherence levels were found to be higher for those women with a history of urinary tract infection compared with those with no past record of infection. In the second group, elderly patients (mean age 87 years) presented with bacteriuria, and their uroepithelial cells were found to be colonized by uropathogens to a significantly greater extent than their controls. The adherent population was reduced during 7-day TMP-SMX antibiotic treatment, but increased posttherapy, particularly in two patients who subsequently became reinfected. The in vitro results showed that uroepithelial cells retain their receptivity to uropathogenic adherence, both during and after treatment. Although antibiotics eradicate uropathogens from the urinary tract, patients remain susceptible to recolonization by uropathogens and are at risk of reinfection after completion of therapy.

(PDF emailed within 1 workday: $29.90)

Accession: 017870710

Download citation: RISBibTeXText

PMID: 3262006

Related references

Effect of antibiotic treatment on uropathogenic colonization of uroepithelial cells from patients with recurrent urinary tract infection. Journal of Urology 133(4 PART 2): 276A, 1985

Adherence of gram-negative uropathogens to human uroepithelial cells. European Urology 13(1-2): 74-78, 1987

Competitive exclusion of uropathogens from human uroepithelial cells by Lactobacillus whole cells and cell wall fragments. Infection and Immunity 47(1): 84-89, 1985

In vitro attachment of Escherichia coli to human uroepithelial cells: variation in receptivity during the menstrual cycle and pregnancy. Journal of Infectious Diseases 148(3): 412-421, 1983

Adherence of cervical, vaginal and distal urethral normal microbial flora to human uroepithelial cells and the inhibition of adherence of gram-negative uropathogens by competitive exclusion. Journal of Urology 131(3): 596-601, 1984

Lectin like proteins from uroepithelial cells which inhibit in vitro adherence of three urethral bacterial isolates to uroepithelial cells. Microbial Ecology in Health & Disease 5(2): 77-86, 1992

Antibiotic treatment and resistance of unselected uropathogens in the elderly. International Journal of Antimicrobial Agents 27(3): 236-241, 2006

An infectious disease and pharmacokinetic perspective on oral antibiotic treatment of uncomplicated urinary tract infections due to multidrug-resistant Gram-negative uropathogens: the importance of urinary antibiotic concentrations and urinary pH. European Journal of Clinical Microbiology & Infectious Diseases 35(4): 521-526, 2016

Antimicrobial susceptibility of uropathogens and outcome following antibiotic treatment for urinary tract infections in primary health care. Enfermedades Infecciosas Y Microbiologia Clinica 24(7): 418-425, 2006

Effect of subinhibitory concentrations of Ciprofloxacin and gentamicin on the adherence of Pseudomonas aeruginosa to Vero cells and voided uroepithelial cells. ChemoTherapy 39(2): 105-111, 1993

Antibiotic resistance pattern in uropathogens. Indian Journal of Medical Microbiology 20(2): 96-98, 2007

Emerging antibiotic resistance among the uropathogens. Indian Journal of Medical Sciences 54(9): 388-394, 2002

Antibiotic resistance trends in paediatric uropathogens. International Journal of Antimicrobial Agents 26(4): 267-271, 2005

Uropathogens of various childhood populations and their antibiotic susceptibility. Pediatric Infectious Disease Journal 10(10): 742-746, 1991

Effect of contraceptives on the adhesion of Escherichia coli to uroepithelial cells. Journal of Infectious Diseases 156(3): 490-494, 1987